Microcrystalline Cellulose (MCC)

Microcrystalline Cellulose (C6H10O5)n FR-Cell/FR-Cell Prime is a white, free-flowing powder prepared by treating alpha-cellulose, obtained as a pulp from fibrous plant material, with mineral acids.

Grades

Grade Sieve Analysis (% Retention) Bulk Density (g/ml) Moisture (%)
60 mesh 200 mesh 100 mesh
FR-Cell 101 ≤ 1.0% ≤ 30.0% 0.25 - 0.34 NMT 7.0
FR-Cell 102 ≤ 8.0% ≥ 45.0% 0.26 - 0.34 NMT 7.0
FR-Cell 103 ≤ 1.0% ≤ 30.0% 0.25 - 0.34 NMT 3.0
FR-Cell 112 ≤ 8.0% ≥ 45.0% 0.26 - 0.35 NMT 2.0
FR-Cell 113 ≤ 1.0% ≤ 30.0% 0.26 - 0.34 NMT 2.0
FR-Cell 200 ≥ 10.0% ≥ 50.0% 0.26 - 0.37 NMT 7.0
FR-Cell 301 ≤ 1.0% ≤ 30.0% 0.34 - 0.43 NMT 7.0
FR-Cell 302 ≤ 8.0% ≥ 45.0% 0.35 - 0.43 NMT 7.0
FR-Cell 105 0.20 - 0.30 NMT 7.0
40 mesh 100 mesh 300 mesh
FR-Cell 12 ≤ 1.0% ≤ 50.0% ≥ 70.0% 0.29 - 0.36 NMT 7.0
FR-Cell 14 ≤ 1.0% ≤ 50.0% ≥ 70.0% 0.34 - 0.45 NMT 2.0

NOTE : Brightness for above grades >88%
NMT : Not more than

Grade Sieve Analysis (% Retention) Bulk Density (g/ml) Moisture (%)
60 mesh 200 mesh 100 mesh
FR-Cell Prime 101 ≤ 1.0% ≤ 30.0% 0.27 - 0.33 NMT 5.0
FR-Cell prime 102 ≤ 8.0% ≥ 45.0% 0.28 - 0.33 NMT 5.0
FR-Cell prime 112 ≤ 8.0% ≥ 45.0% 0.28 - 0.34 NMT 1.5
FR-Cell prime 200 ≥ 10.0% ≥ 50.0% 0.31 - 0.38 NMT 5.0
FR-Cell prime 802 ≤ 0.5% 5.0% - 30.0% 0.13 - 0.23 NMT 5.0

NOTE : Brightness for above grades >90%

Specifications

Tests Acceptance Criteria
Identification A IR Scan
Identification B (lodinated zinc chloride solution) Violet-blue color
Identification C (Degree of polymerization) NMT 350
Residue on Ignition NMT 0.1%
Conductivity NMT 75 µS/cm
pH 5.0-7.5
Loss on Drying NMT 7.0%
Water-soluble substances NMT 0.25%
Ether-soluble substances NMT 0.05%

Microbial Tests

Tests Acceptance Criteria
Total aerobic microbial count NMT 1000 cfu/g
Total combined molds and yeasts count NMT 100 cfu/g
Staphylococcus aureus Absent
Pseudomonas aeruginosa Absent
Escherichia coli Absent
Salmonella species Absent

NMT : Not more then
CFU - Colony forming unit

Sample Request

FR-Cell/FR-Cell Prime

Main Applications

FR-Cell 101

  • Fine standard grade, very high compactibility, suited for wet granulation.

FR-Cell 102

  • Direct compression, better flow, high compactibility.

FR-Cell 103

  • Same quality as grade 101, but low moisture content for water sensitive actives.

FR-Cell 112

  • Same quality as grade 102, but very low moisture content, suited for direct compression.

FR-Cell 113

  • Fine particle size,
  • low moisture content, suited for dry granulation.

FR-Cell 200

  • Larger particle size, excellent flow for direct compression formulations.

FR-Cell 301

  • Same quality as grade 101, but increased bulk density and improved flow properties, potential for making small tablets.

FR-Cell 302

  • Same quality as grade 102 with higher bulk density, suited for high speed tableting.

FR-Cell 105

  • Very fine grade, masks bitter taste, high compactibility.

FR-Cell 12

  • Coarse grade, good compactibility, high

FR-Cell 14

  • Same quality as grade 12 but very low moisture content for water sensitive actives.

Pharmacopoeia Compliance

USPLogo BritishPharmaLogo EDQMLogo JapanesePharmaLogo IndianPharmaLogo